LGR5 and neoplasm: However, while LGR5 has facilitatedour understanding of CSCs in this tumor type over the past two decades, the role ofLGR5+ CSCs in tumor relapse and metastasis has been challenged (Morral et al. 2020, Canellas-Socias et al.2022), Therefore, CSC markers should be handled with caution, and a singlemarker may not identify CSCs that satisfy all CSC properties.