Subsequently, Merlos-Suárez andcoworkers, using murine colorectal tumor models, showed that the ISC program definesa CSC niche within colon cancer using the markers EphB2 and Lgr5 (Merlos-Suarez et al. 2011),and in lineage tracing experiments using human organoids, as shown by Cortina andcoworkers (Cortina et al.2017) and Oost and coworkers (Oostet al. 2018). This evidence concerns the gene LGR5 and colonic neoplasm.