INS and obesity due to melanocortin 4 receptor deficiency: Numerous studies focusing on children and adolescents with overweight and obesity consistently highlight the positive impact of regular exercise on body composition, including body mass index (BMI) score, as well as improvements in metabolic abnormalities and biochemical variables, such as insulin resistance markers, inflammatory markers, and adipocytokines (Alberga et al., 2015; Kelley et al., 2015).