(−): Ear thickness; PCNA expression; psoriasis-like lesions; TNF-α, IFN-γ, IL-1β, IL-6, IL-12, IL-17, IL-22, IL-23 expression; TH-17 differentiation and keratinocytes proliferation; TH-1 recruitment in the epithelium; inflammatory response. The gene discussed is IL1B; the disease is psoriasis.