YWHAQ and Creutzfeldt Jacob disease: Confirmation of the diagnosis for both probable and possible CJD may be supported by findings such as typical periodic sharp wave complexes on EEG, elevated levels of the protein 14-3-3 in cerebrospinal fluid, or MRI hyperintensity in the putamen and caudate nucleus or at least two cortical regions observed in either fluid-attenuated inversion recovery (FLAIR) or diffusion-weighted imaging (DWI) sequences [9].