ETS1 and head and neck squamous cell carcinoma: Interaction between TRPM7 and NFATc2 has been associated with chemotherapeutic resistance and metastasis in head and neck squamous cell carcinoma [25]. There is a crosstalk between NFATc2, NFKB1/RELA, and the core-regulatory element (CRE) in the ETS1 promoter region in metastatic breast cancer that regulates ETS1 gene transcription [26].