This study primarily focuses on the renal and systemic effects of SGLT2 inhibitors, particularly their interaction with renal tubular Na, water, and Cl homeostasis in the context of HF. While the study's primary focus is on SGLT2 inhibitors rather than acetazolamide, its findings underscore the significance of proximal tubular function and Cl handling in managing HF. This evidence concerns the gene SLC5A2 and hydrops fetalis.