Studies have shown that RAAS activation in HF is closely linked to fluid retention and reducing RAAS markers is associated with improved outcomes [23]. No significant differences were observed in noradrenaline (425±81 pg/mL vs. 455±91 pg/mL; p=0.12) or AVP levels (2.7±1.1 pg/mL vs. 3.0±1.3 pg/mL; p=0.28) between groups [24]. The gene discussed is AVP; the disease is hydrops fetalis.