2) This article does not provide a detailed study on how the RUNX family members, including RUNX1, RUNX2, and RUNX3, specifically regulate the mechanisms of tumor-infiltrating CD8+ T cells and CD103+CD8+ T cells in colorectal cancer, as well as the functional roles they play in the anti-tumor immune response within the CRC microenvironment. This evidence concerns the gene ITGAE and colorectal cancer.