ITGAE and colorectal cancer: In this study, our analysis of correlation between the expression levels of RUNX1, RUNX2 and RUNX3 in infiltrating CD8+T and CD103+CD8+T cells in colorectal cancer, implicated that the transcription factors RUNX1, RUNX2, and RUNX3 might exhibit a synergistic interaction effect within clusters and mutually influence each other (Figure 9).