Moreover, Table 5 revealed that individuals with a pathological grade of III+IV exhibit a markedly higher risk of mortality (multi-variate: HR=2.416, 95% CI: 1.085-5.398, P=0.031) in comparison to those with a pathological grade of I+II, even after adjusting for variables such as gender, age, tumor size, infiltration of CD8+T, infiltration of CD103+CD8+T, and other relevant factors. Here, ITGAE is linked to neoplasm.