A more detailed review of the literature for associations of leptin (and of the other nine top consistent mediators: CPM, F9, FGF21, PRSS8, LILRA5, CA14, VWA1, BAIAP2, and WFIKKN2) with dementia and CVH traits is provided in OSM 7 (Appendix I). The gene discussed is LEP; the disease is dementia.