Cognitive aging has been frequently linked with proteins such as C‐reactive protein (CRP), interleukin‐6 (IL‐6), tumor necrosis factor alpha (TNF‐α), apolipoprotein E (ApoE), and fibrinogen,39, 40, 41, 42 which can potentially mediate or mediate the associations between CVH and dementia‐related MRI outcomes through several mechanisms.43, 44, 45, 46. The gene discussed is TNF; the disease is dementia.