APOE and Mental deterioration: We hypothesized that in adults aged ≥ 70, multidomain interventions are more effective for reducing the risk of all‐cause and AD dementia, and cognitive decline, in high‐risk subgroups defined by risk factors including high body mass index (BMI), cholesterol, and blood pressure; limited physical activity; low education; and/or an unfavorable APOE ε4 genotype (ε4 hetero‐ or homozygotes), and are less effective at older ages.