In a multivariate binary logistic regression model including potential confounders (age, gender, arterial hypertension, ECMO therapy, SOFA) with Ang II, Ang 1–7, ACE2, and AA2R, only age, Ang II, Ang 1–7, and ACE2 remained significant predictors of 60-day survival (Table 4). The gene discussed is ANGPT1; the disease is Hypertension.