To find out whether a decrease of virus load observed in the presence of Iristatin results in a decrease of IFN or ISGs, we measured gene expression of IFN-β and four interferon-stimulated genes, namely ISG15, CXCL-10, OASL2, and IFIT2 in skin tissue two and 5 days after Hypr infection. The gene discussed is ISG15; the disease is infection.