Gene expression of CPT-1b (Cpt1b), responsible for the mitochondrial uptake of fatty-acyl-CoA was not affected (Fig. 2.8), whereas expression of the dehydrogenase enzymes (Acadm, Acadl), required for the conversion to acetyl-CoA, were downregulated in prolonged sepsis (Fig. 2.9). The gene discussed is ACADL; the disease is Sepsis.