Gene expressions of enzymes of the pyruvate dehydrogenase complex (Pdha1, Pdhb) were unaffected or decreased throughout sepsis (Fig. 3.18), whereas pyruvate dehydrogenase kinase 3 (Pdk3), but not 1 (Pdk1), was upregulated (Fig. 3.19). The gene discussed is PDK3; the disease is Sepsis.