NEDD4 and kidney cancer: Neuronal precursor cell developmentally downregulated protein 4 (NEDD4) which belongs to the NEDD4 family of HECT-type E3 ubiquitin ligases, a proto-oncogene targeting the tumor suppressor PTEN (Phosphatase and TENsin homolog deleted on chromosome 10) involved in lysosomal and proteasomal degradation in kidney cancer cells has been shown to target LGR5 in vitro.