High LGR5 expression enhanced tumor proliferation through WNT/β-catenin in lung [13], gastric [95], CRC [40, 63, 75, 76, 78–87, 89, 91], hepatocellular carcinoma (HCC) [99, 100], breast [57, 74], cervical [41, 58], endometrial [94], oesophageal [39], bone [43], and brain [71–73] cancers. The gene discussed is LGR5; the disease is neoplasm.