High LGR5 expression enhanced tumor invasion in cervical [58], rectal [12], CRC [49, 76, 77, 80, 83, 85, 86, 104–108], lung [13, 109], ESCC (oesophageal squamous cell carcinoma) [39], thyroid [110], and hepatic [99] cancers. Here, LGR5 is linked to esophageal squamous cell carcinoma.