Conditional knock-out of VPS34 in cardiomyocytes in mice (Mck/Vps34−/−) increased the heart size and heart/body ratio, which was associated with the accumulation of αB-crystallin (CryAB), left ventricular hypertrophy, and decreased heart contractility [23]. This evidence concerns the gene PIK3C3 and left ventricular hypertrophy.