PIK3C3 and colonic neoplasm: For example, mTORC1-mediated Ser550 and Ser571 phosphorylation of UVRAG, an essential component of VPS34 Complex II, activated VPS34 and enhanced cell survival after long-term starvation [83]; however, mTORC1-induced Ser498 phosphorylation of UVRAG inactivated VPS34 and decreased endosome maturation, which promoted the proliferation of HCT116, a colon cancer cell line [84].