TARDBP and Alzheimer disease: Other possible mechanisms leading to increased WMHs in relation to AD‐TDP type‐α could be similar to those proposed in FTLD‐TDP, including Wallerian degeneration from TDP‐43 pathology deposition, which leads to axonal loss and demyelination14, 15, 16, 66; reactive gliosis and spongiosis causing intra‐myelinic edema67; or increased neuroinflammation leading to reactive oxygen species production and oxidative stress.