In AD with TDP‐43 pathology (AD‐TDP), there are two main types of TDP‐43 inclusions: type‐α, where inclusions mimic those seen in FTLD with TDP‐43 (FTLD‐TDP) and include neuronal cytoplasmic inclusions (NCIs), neuronal intranuclear inclusions (NIIs), dystrophic neurites (DNs), fine neurites of the hippocampus (FNs), and perivascular inclusions (PVs); and type‐β, where TDP‐43 co‐deposits with tau neurofibrillary tangles (NFTs) in the setting of elevated AD neuropathologic changes (ADNCs).25, 26. This evidence concerns the gene TARDBP and Alzheimer disease.