These studies indeed found a relationship between greater WMH burden and pathologically confirmed FTLD‐TDP type A16, 18, 27 or frontotemporal dementia (FTD) cases with progranulin (GRN) mutations,27, 41, 57, 58, 59 which typically present with underlying FTLD‐TDP type A pathology.53, 54. This evidence concerns the gene GRN and frontotemporal dementia.