In the HFD‐50% the upregulated genes were involved in tryptophan, cholesterol, glycerolipid, glycerophospholipid, and nitrogen metabolism, PPAR, JAK–STAT, AGE‐RAGE signaling, phosphatidylinositol signaling, antifolate resistance and fatty acid‐lysine‐valine‐leucine and isoleucine degradation (Figure 6b) while the downregulated genes were involved in MAPK and cAMP signaling, circadian rhythm, amphetamine addiction, hypertrophic cardiomyopathy, protein digestion and absorption, estrogen signaling, cGMP‐PKG signaling, and calcium signaling (Figure 7b). Here, RENBP is linked to hypertrophic cardiomyopathy.