Klf10, also known as TGFβ‐inducible early gene‐1 is a transcription factor, was recently identified as an important regulator of obesity and insulin resistance (Wara et al., 2020) and acts as a downstream effector of exercise to combat nonalcoholic steatohepatitis (Luo et al., 2024). Here, KLF10 is linked to metabolic dysfunction-associated steatohepatitis.