Data indicate that the tumour microenvironment (TME) also differs between men and women, with women showing higher levels of CD4+ lymphocytes in tumour tissue, lymph nodes and uninvolved colon tissue compared with men; CD8+ levels in tumour and lymph nodes were similar in the two sexes, but women showed greater CD8+ infiltration in uninvolved peri-tumoural tissue [54]. The gene discussed is CD4; the disease is neoplasm.