IL1B and inflammatory bowel disease: Impaired nutrition and growth in childhood can have short-term and long-term consequences if not treated effectively.28,29 The reduced weight in IBD may have multiple causes, such as decreased caloric intake due to the anorexic effects of proinflammatory mediators like interleukin (IL)-1β and TNF-α, malabsorption of food components, and/or early gastrointestinal symptoms, including early satiety, pain, and nausea.30,31 Reduced food intake may be caused by pain while eating, fear of diarrhea after meals, or poor tolerance of foods.