Thus, we analyzed the relationship between the expression of DIO2 and several immunomodulatory genes and molecules by gene co-expression analyses in the TISIDB Database and we found that in most cancers DIO2 expression was significantly correlated with immunoinhibitory and immunostimulatory genes, as well as Major Histocompatibility Complex (MHC) molecules, chemokines, and chemokine receptors (Fig. 5B, C and Supplemental Fig. S13A-C). The gene discussed is HLA-C; the disease is cancer.