It is important to emphasize the following points: Anx administration-induced brain CaP deposition was associated with brain infarction; blockade of Anx-induced Cap deposition by a monomeric β actin treatment mitigated brain infarction; and Anx siRNA-mediated alleviation of neuronal CaP deposition reduced brain infarction. The gene discussed is ACTB; the disease is brain infarction.