CD4 and hepatocellular carcinoma: On the Maturation stages of T cell panel, Naive CD4 + %CD4 + and TD DN (CD4-CD8-) %T cell could decrease the risk of HCC while CD8 on EM CD8br could increase the risk of HCC.CD4 + T cells exert an integral role in immune responses and tissue homeostasis [28]. A recent study suggested that the number of CD4 + T cells displayed a remarkable impact on the survival and prognosis of HCC patients [29].