OR of CX3CR1 on CD14 + CD16 + monocyte on HCC risk was estimated to be 0.780 (95% CI 0.669–0.910, P = 1.602 × 10–3) by using IVW approach.Similar result was observed by using weighted median approach (P = 1.602 × 10–3). Here, CX3CR1 is linked to hepatocellular carcinoma.