The testicular microvascular supply shortage related to hyperglycemia remains the obvious mechanism correlated to the testicular cell apoptosis and destruction where the decreased vascular endothelial growth factor (VEGF) expression and impaired angiogenesis caused by chronic hyperglycemia could lead to inadequate blood supply to the testicular tissue [10], resulting in hypoxia and increased oxidative stress which in turn trigger apoptosis of testicular cells and ultimately lead to testicular destruction [11]. This evidence concerns the gene VEGFA and Hyperglycemia.