Within these pathways, we identified several gene transcripts being upregulated in HCC from p53LKO mice, including transferrin receptor, known for mediating the transport of di-ferric transferrin iron, and divalent metal iron transporters, Slc11a1 and Slc11a2 (Nramp1 and Nramp2, respectively), and Cybrd1 (Dcytb1) (Fig. 2f), while the expression of hepcidin and its upstream regulators (such as Hfe and Bmp6) was significantly downregulated (Fig. 2f). This evidence concerns the gene HFE and hepatocellular carcinoma.