However, KRAS mutations, primarily single-base missense mutations occurring at codons 12, 13 or 61, have been found to drive tumourigenesis of pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC) and non-small-cell lung cancer (NSCLC) [23]. The gene discussed is KRAS; the disease is pancreatic ductal adenocarcinoma.