As PKM2 serves as a critical molecule downstream of the vital enzyme PFKP in the glycolytic pathway, it is hypothesized that the regulatory effect of FTO on PKM2 in colon cancer is likely to be exerted through the modification of PFKP at the m6A level by FTO, thereby indirectly affecting the expression of PKM2. The gene discussed is FTO; the disease is malignant colon neoplasm.