The lack of differences in the areas covered by melanoma cells between the tg(mift:xmrk) + tyrp:X.mal_adgre5 and tg(mitf:xmrk), as well as the striking reduction of pigmentation of tg(mift:xmrk) + tyrp:X.bir_adgre5, suggests that adgre5 acts indeed as a tumor suppressor. The gene discussed is ADGRE5; the disease is neoplasm.