BCL2 and melanoma: Although it has been demonstrated that adgre5, under apoptotic conditions, can increase tumor cell viability by inhibition of caspase activation and modulation of anti- and pro-apoptotic members of the BCL-2 superfamily (Hsiao et al. 2015), it has also been demonstrated that G protein-coupled receptors inhibit melanoma tumor growth and metastasis (Xu et al. 2006).