Furthermore, cardiac specific Hif-1α knockout is able to reverse pathological myocardial remodeling in the α-MHC719/+ mouse model as evidenced by decreased ventricular hypertrophy, myocardial fibrosis, diastolic dysfunction, oxidative stress, and cardiomyopathic RNA and protein profiles. The gene discussed is HIF1A; the disease is Myocardial fibrosis.