Another issue needs to be investigated is that we mainly focused on the ERRα/PGC1β in our model, ERRα could also interact with PGC1α (Figure S7H), whether ERRα prefer to interact with PGC1α or PGC1β, these two types of combination exhibit same or different transcriptional function in ALP and RCC, it needs more comprehensive investigation in the future. This evidence concerns the gene ESRRA and renal cell carcinoma.