p300/CBP-mediated acetylation of ERRα at the DBD (K100, K125, K138, and K146) promoted its nucleus transition, affinity toward targeting DNA and enhanced the transcriptional performance, which maintained the autophagy flux and tumorigenesis of RCC cells by increasing the expression of LAMP2 and VAMP8 (Figs. 6G, H and S4A). Here, LAMP2 is linked to renal cell carcinoma.