ESRRA and neoplasm: Moreover, ERRα have been wide documented to crosstalk with hypoxia/HIFs signaling in different carcinomas through directly interacting with HIFs to increase HIFs stability or activating hypoxia-related genes in HIFs-independent manner [49], but whether ERRα could interact with HIFs is unclear, we performed IP in Caki-1 and didn’t detect the interaction between ERRα and HIF-2α (data not shown), but we found that VEGFA intensity were largely decreased in the tumor tissues of shERRα (Figure S7G), indicating that ERRα might participate with hypoxia signaling in HIFs-independent manner.