In addition, our proteomics data revealed that multiple metabolism pathways (such as carbon metabolism, amino acids biogenesis, and pyrimidine metabolism) and apoptosis were associated with ERRα in RCC (Figs. 2B and S7A), so we verified many metabolic enzymes and apoptosis-related proteins using WB and IHC. The gene discussed is ESRRA; the disease is renal cell carcinoma.