The results found that shERRα decreased MDH2 and ACO2 expression, and increased the levels of IDH3B, CTSB, and Cytochrome C in RCC cells and tumor tissues (Figure S7B and S7C), and promoter analysis revealed that ERRα might directly bind to promoter regions and modulate transcription of CTSB, Cytochrome C, ACO2 and MDH2 (Figure S7D). Here, MDH2 is linked to renal cell carcinoma.