A previous study demonstrated that ERRα acetylation mediated by p300/CBP-associated factor (PCAF) at Lys-129, Lys-138, Lys-160, and Lys-162 crippled its transcriptional activity [35], but the present study data indicated that hypoxia induced a higher degree of acetylation coupled with stronger transactivation of ERRα in RCC cells. This evidence concerns the gene ESRRA and renal cell carcinoma.