Furthermore, IHC staining results revealed that treatment with XCT-790 and CQ significantly repressed the expression of Ki67 (Figs. 3F), accompanied by a decrease in vascular intensity within tumors (Figs. 3G), suggesting that ERRα-mediated autophagy-lysosome pathway might also affect angiogenesis in RCC as reported previously [7, 30, 31]. The gene discussed is ESRRA; the disease is renal cell carcinoma.