ESRRA and renal cell carcinoma: To confirm the significance of ERRα-mediated autophagy-lysosome homeostasis in RCC progression, we performed cell growth monitoring and Transwell assays, and the results revealed that trehalose-induced release of autophagy flux, which was blocked by shERRα, partially rescued the suppression of the proliferation and metastasis of RCC cells (Figs. 3A, B).