ESRRA and renal cell carcinoma: Moreover, mouse model showed that WT ERRα overexpression promoted the tumorigenesis of RCC cells in vivo, while the 4KR mutant had only a slight promotion effect on tumor growth, and WT ERRα coupled with CBP30 also impaired ERRα acetylation-mediated tumorigenesis of RCC cells (Figs. 7D–F).