EP300 and renal cell carcinoma: The label-free quantitative proteomics analysis revealed that ERRα promoted lysosome-dependent autophagy flux by maintaining the fusion of autophagosomes with lysosomes in RCC; this regulation of ERRα on autophagy and tumorigenesis was dependent on hypoxia-induced ERRα acetylation, which was mediated by p300/CREB-binding protein (CBP) and enhanced its transcriptional activity and protective effect of autophagy in RCC.