Increased levels of A. muciniphila in responders to anti-PD-L1 therapy are associated with greater activation of dendritic cells, leading to increased IL-12 secretion, enhanced migration of CD4 + CCR9+ memory T cells, and CD4 + CXCR3 + T cells from mesenteric lymph nodes to tumor-draining lymph nodes, thereby increasing antitumor responses (Zhou et al, 2022). This evidence concerns the gene CD4 and neoplasm.