We injected PDO6, driven by KRASQ61H, PIK3CAN345I and APCG1288* mutations (TP53 status = wild type), into the flanks of immunodeficient CB17 Scid beige mice, resulting in the development of tumors that resemble moderately differentiated human CRC (Fig. 7i,j). This evidence concerns the gene TP53 and colorectal carcinoma.