Confocal microscopy revealed similar severe mitotic abnormalities in 2015-treated, murine organoids (KAP) and patient-derived CRC organoids (PDO5), as well as in KAP organoids with shRNA-mediated knockdown of Mapk14 (Fig. 4h and Extended Data Fig. 6a,b). The gene discussed is MAPK14; the disease is colorectal carcinoma.