CD103+CD69+CD4+TRM cells were found in the mucosa of patients, and the density of them was positively correlated with disease severity.449 Intriguingly, the deletion of Hobit and Blimp, the important TFs for the development of TRM cells, indeed induced IBD remission.449 Activated MAIT cells derived from IBD patients also exhibit high IL-17-secreting phenotypes, related to aggravating inflammation.450. Here, CD69 is linked to inflammatory bowel disease.