In TME, iNKT cells recognize cancer cells or others expressing CD1d-lipid antigen and clean them by secreting cytotoxic molecules.259 They also activate other effector immune cells, such as DCs and CD8+T cells, and simultaneously repress immunosuppressive cells to amplify the immune response.110,267 In pancreatic cancer liver metastasis and chronic lymphocytic leukemia model, iNKT cells reverse immunosuppressive TME by promoting the infiltration of effector T cells or restraining TAMs.650,651 Nonetheless, iNKT cells showed cancer-protective roles in some cancers.609. This evidence concerns the gene CD1D and cancer.