SELL and neoplasm: In the tumor microenvironment (TME), the scRNA-seq of NSCLC tumor tissues identified two kinds of TRNs, including tumor-associated neutrophils (TANs) and normal adjacent tissue-associated neutrophils.84 TANs downregulate CXCR2 and SELL, the markers of mature neutrophils, whereas normal adjacent tissue-associated neutrophils highly express them.84 The common markers of TANs include OLR1, VEGFA, CXCR4, and CD83.84 These TANs are deeply involved in TME reshaping and regulation of cancer immunity.