In liver cancer, NK cells have been found to accelerate cancer progression by upregulating immunosuppressive molecules, including CD96, PD-1, and TIGIT, and are identified as a poor prognostic factor.112 In contrast, trNK cells have higher degranulation levels for cytotoxic molecules in ovarian cancer and NSCLC to promote anti-cancer ability.626,664 Considering the advances in NK cell therapies such as CAR-NK therapy, it is essential to further elucidate the role of trNK cells in cancer. This evidence concerns the gene CD96 and cancer.