In the tumor microenvironment (TME), the scRNA-seq of NSCLC tumor tissues identified two kinds of TRNs, including tumor-associated neutrophils (TANs) and normal adjacent tissue-associated neutrophils.84 TANs downregulate CXCR2 and SELL, the markers of mature neutrophils, whereas normal adjacent tissue-associated neutrophils highly express them.84 The common markers of TANs include OLR1, VEGFA, CXCR4, and CD83.84 These TANs are deeply involved in TME reshaping and regulation of cancer immunity. Here, CXCR4 is linked to neoplasm.