IL17A and Granuloma: For example, γδT cells provide a protective role against MTB infection by producing IL-17, which is important for the maturation of granulomas.549,550 Moreover, IL-17 and IL-22 produced by lung-resident ILC3s initiate early innate immune responses.551 CD103+CD69+MAIT cells aggregating in the tuberculous pleural effusions highly secrete IFN-γ and GZMB for MTB clearing.552 In summary, various lung-TRICs participate in regulating local immunity upon MTB infection.