For example, CD103+CD69+CD8+TRM cells have been identified as the predominant T cell population in the insulitic lesion of type 1 diabetes mellitus rather than classical cytotoxic CD8+T cells, which indicates the potentially important roles of TRM cells in diabetes mellitus.461 Studies on uterus-related autoimmune diseases showed that uterus-γδT cells upregulate IL-17 production after being activated, which may cause disease progression.105,462,463. This evidence concerns the gene CD8A and type 1 diabetes mellitus.