For example, intra-cervicovaginal mucosal immunization of female mouse models with human HPV vectors induces CD103+CD8+TRM cells that upregulate cytokines and perform cytotoxicity.17,689 And in the HPV E6/E7 oncoproteins-transformed TC-1 mouse model, the cervicovaginal vaccination with HPV E6/E7 recombinant vaccinia vaccine induces robust anti-tumor response harnessing CD103+CD8+TRM cells.690. This evidence concerns the gene ITGAE and neoplasm.