For example, mucosal immunization is much better than intra-muscular or subcutaneous ways to elicit the formation of CD8+TRM cells in mucosal tumor sites.692 The superior effect of CD8+TRM cells over effector CD8+T cells in the same vaccination route may be due to the persistent mucosal location by which TRM cells provide rapid and long-term protection against tumors. Here, CD8A is linked to neoplasm.