For example, CD8+TRM cells located in lung tissues rapidly secrete protective molecules such as IFN-γ and IL-2 after confronting with RSV, SARS-CoV-1, and SARS-CoV-2.151,530 In mice model with virus infection, brain-CD8+TRM cells provide immune defense against the reinfection of mouse polyomavirus,531,532 and tissue-resident ILC1s can make an early robust immune response against mouse cytomegalovirus in the liver.484 Generally, most TRICs contribute to protective immunity in response to various virus infections. This evidence concerns the gene IFNG and viral infectious disease.