There were no significant differences in the proportion or number of splenic CD8+ T cells that produced IFN-γ in response to ex vivo restimulation with the LCMV-derived GP33–41, GP34–41, GP276–286, NP205–212, or NP396–404 peptides between prothrombin-depleted and control mice, with the expected hierarchies among these responses during LCMV clone 13 infection (Figure 4D) (17). Here, CD8A is linked to infection.