In contrast to other models of lethal immunopathology during chronic infection with LCMV clone 13, we did not observe enhancement of pathological damage to lungs (20, 29–31), liver (31–33), heart (19), kidney (34), brain (35), or intestines (36, 37) linked to fatal outcomes of infection in prothrombin-depleted animals (Figure 1C and Supplemental Figure 2, A and B). This evidence concerns the gene F2 and infection.