NFKB1 and Nephropathy: Studies have confirmed that the loss of Sirt1 during LPS-induced inflammation results in excessive neutrophil infiltration, leading to kidney damage.188 Interestingly, studies have demonstrated a decline in the expression of Sirt1 with age in the brains, livers, skeletal muscles, and white adipose tissue of mice, as well as in the brains of rats.189,190 Meanwhile, NF-κB activation increased in elderly individuals.191 These findings suggested an association between aging, deacetylation of NF-κB, and neutrophil excessive activation, potentially leading to PD.