In addition to CHIP, which slightly increases the risk of leukemia, myelodysplastic syndrome (MDS) [133, 134], acute myeloid leukemia (AML) [135, 136], acute lymphoid leukemia (ALL, T-cell ALL) [71, 135], and chronic lymphoid leukemia (CLL) occur frequently [137]. Here, STUB1 is linked to acute lymphoblastic leukemia.