ACOD1 and bacterial infectious disease: Among these, GBP2, CXCL9, and IRG1 represent some of the pathways involved in the protective response: GBP2, a member of the GTPase family, drives macrophages toward an inflammatory state (Li et al., 2023) while combating bacterial infection through vacuole disruption and pyroptosis induction (Meunier et al., 2014).