Other activities of DNMTi that can cooperate with PARP inhibition include the re-activation of tumor suppressors [41]; reduction of MutL-alpha and MutS alpha DNA mismatch repair protein levels [42]; and reduction of low fidelity DNA repair pathways such as non-homologous end joining (NHEJ), alternative non-homologous end joining (alt-NHEJ), and intra-strand crosslink repair [24]. The gene discussed is PARP1; the disease is neoplasm.