PLOD1 and Infertility: Loss of pulsatile LH secretion during lactation and consequent lactational infertility may be caused by the loss of kisspeptin-mediated stimulation of GnRH secretion (Yamada et al., 2007; Liu et al., 2014; Roa et al., 2006; Ladyman and Woodside, 2014; True et al., 2011; Brown et al., 2014; Xu et al., 2009).