The observed disruption of lactational infertility in Prlrlox/lox/Kiss1Cre mice is particularly remarkable given that Prlr deletion is restricted to arcuate kisspeptin neurons in this model (Brown et al., 2019), and prolactin action on RP3V kisspeptin neurons (Sonigo et al., 2012; Kokay et al., 2011) and on gonadotrophs in the pituitary gland (Hodson et al., 2010; Tortonese et al., 1998; Henderson et al., 2008) are unaffected. The gene discussed is KISS1; the disease is Infertility.