While E. faecalis-colonized Il10−/− mice developed colitis and CRC,3,7 surprisingly, no increased colonic inflammation was observed in E. faecalis-colonized Il10−/−/Gsta4−/− mice compared to sham-treated DKO mice (Figure 2c,d) and Supplementary Figure S2). The gene discussed is GSTA4; the disease is colorectal carcinoma.