In addition, we recently showed that inactivation of GSTA4 in human CRC cells inhibits proliferation and cancer growth.14 Whether Gsta4-deficiency promotes ferroptosis in colonic epithelial cells or other stromal cells besides macrophages, and thereby contributes to reduced colitis in E. faecalis-colonized Il10−/−/Gsta4−/− mice, remains unclear. Here, IL10 is linked to colitis.