Macrophage-specific expression of GPX4 decreased in both human COAD and READ compared to the corresponding normal tissues (p < 0.001 and 0.01 for COAD and READ, respectively; Figure 7e,f), suggesting that decreased expression of GSTA4 may be associated with macrophage ferroptosis in human colorectal cancer. The gene discussed is GSTA4; the disease is colorectal cancer.