IL10 and colitis: We have previously shown that E. faecalis-polarized macrophages produce 4-HNE that induces colitis and CRC in Il10−/− mice via MIBE.3,7 Because GSTA4 specifically detoxifies 4-HNE, we explored the role of it in murine colitis-associated CRC using an Il10−/−/Gsta4−/− (DKO) model.