PDE (phosphodiesterase) has been shown to regulate the activation of platelets and their interaction with inflamed endothelial cells.41 MEGF10 mediates efferocytosis as a receptor for C1q which signals apoptosis.42 Interestingly, another candidate, MERTK can collaborate with both TIMD4 and MEGF10 on efferocytosis.43,44 NPTX1 together with its family members NPTX2 and NPTX receptor has also been implicated in complement regulation45 and cognitive impairment.46 The gene discussed is TIMD4; the disease is Cognitive impairment.