PEAR1 and snowflake vitreoretinal degeneration: PEAR1, also known as JEDI (Jagged and Delta protein) or MEGF12 (multiple epidermal growth factor-like domains protein 12), mediates the phagocytosis of apoptotic neurons.35 Moreover, PEAR1 has been identified as a high-affinity receptor for SVEP1 (Sushi, von Willebrand Factor type-A, EGF, and pentraxin–domain containing 1) protein.36 Prior human studies have observed SEVP1 in its associations with inflammation in atherosclerotic plaques, WMH, and dementia.37 It will be of interest to investigate whether the interaction between PEAR1 and SVEP1 plays a role in SVD.