The gene HEXIM1 is located downstream of PLCD3 (Phospholipase C-delta-3), which has been mapped to a GWAS signal for blood pressure.47 Further research could examine whether it is the HEXIM1-regulated inflammation or PLCD3-linked hypertension that is causal for SVD or whether they correspond to different SVD mechanisms. This evidence concerns the gene HEXIM1 and snowflake vitreoretinal degeneration.