Using cross-sectional and survival analyses in the UKB-PPP cohort, 7 proteins (COL2A1, EPHA2, APOE, FLT4, PDE5A, TIMD4, and METAP1D) were found to be associated with information processing speed, visuospatial memory, incident all-cause dementia, or incident any stroke, with their effect directions consistent with the MR findings. The gene discussed is PDE5A; the disease is Stroke.