MR evidence supported 1 protein (COL2A1) associated with LS and 12 additional proteins (EPHA2, APOE, PEAR1, FLT4, TIMD4, PDE5A, MEGF10, MERTK, NPTX1, HEXIM1, METAP1D, and CD46) associated with ≥1 neuroimaging features of SVD. The gene discussed is TIMD4; the disease is Leigh syndrome.