A recent study by Li et al. (8) employing an MCF-7 xenograft mouse model of BC found that TAM treatment altered gut microbiota composition, enriching taxa positively correlated with inflammation, including Prevotellaceae_UCG_001 and Akkermansia; concomitant upregulation of inflammatory cytokines such as IL-6, IFN-γ, and IL12P70 suggested a state of inflammation post-TAM exposure. Here, IL6 is linked to breast cancer.