As shown in Fig. 7C, infection assays showed that for CVA2, CVA3, CVA4, CVA5, CVA6, CVA8, CVA10, and CVA12, high viral titers were detected in wild-type RD cells, and a striking reduction in viral titers was observed in ΔKRM1 cells, confirming the conclusion of a previous study that these enteroviruses were dependent on KRM1 protein for efficient infection (17). Here, KREMEN1 is linked to infection.