In pancreatic cancer, UPP1 mediates the redox balance, survival, and proliferation of tumor cells under hypoxic conditions (Nwosu et al., 2023), and considering the enrichment of O2 transport-related enzymes, the UPP-mediated hypoxic adaptation mechanism may also be an important participant in Postmenopausal Hypertension. Here, UPP1 is linked to familial pancreatic carcinoma.