In a study of patients with RAO without visible emboli, among those with vascular risk factors (diabetes, hypertension, dyslipidemia, AF, etc.), approximately 50% of them also had thrombophilia risk factors, such as factor V Leiden mutation or methylenetetrahydrofolate mutation, which is associated with hyperhomocysteinemia. The gene discussed is F5; the disease is Rare hereditary thrombophilia.