At baseline, within 14 days prior ICI initiation, 1282 (39.0%) patients had cachexia as defined by the Fearon consensus criteria, 1641 (50.0%) patients had a WLGS score ≥ 2, 1806 (55.0%) patients had an NLR > 3, 1087 (33.1%) patients had an albumin < 3.5 g/dL, and 1318 (40.1%) patients had a PNI < 44. This evidence concerns the gene ALB and Cachexia.