A comparative analysis of the activity levels of these six pathways between the SETD4 high‐ and low‐expression groups revealed that SETD4 expression correlated positively with DNA damage response and PI3K/Akt pathway activity and negatively with Hormone_a, Hormone_b, cell cycle, and EMT pathway activity across various cancers (Figure 4C). This evidence concerns the gene SETD4 and cancer.