Yao et al. investigated how the upregulation of SLC9A7/NHE7 (solute carrier family 9 member A7) in hepatocellular carcinoma (HCC) enhances the ability of tumor cells to take up small extracellular vesicles (sEVs) through macropinocytosis. Here, SLC9A7 is linked to hepatocellular carcinoma.