BCL2 and cancer: In vivo mouse xenograft models of Wnt-driven cancer showed suppression of tumour growth, angiogenesis and invasion with treatment of 55.104 Similarly, peptides were derived from Bcl-2-interacting mediator of cell death (BIM) to target antiapoptotic B-cell lymphoma 2 (BCL2) family proteins.105,106 The BIM BH3 helix (146IWIAQELRRIGDEFNAYYARR166 (56)) was modified with i, i + 4 hydrocarbon stapling at positions 154 and 158, giving peptide 57 (146IWIAQELRS5IGDS5FNAYYARR166).