EGFR and cancer: This has been applied to targeting the epidermal growth factor receptor (EGFR) which is overexpressed in cancer.32 EGFR forms an asymmetric dimer and disruption of the dimerization could inactivate the kinase, which was explored by mimicking the EGFR dimerization arm residues 269YNPTTYQM278 (5) which form a β-hairpin (Fig. 6).33