One model in particular, based on inoculation of B16 melanoma cells into the skin followed by adoptive transfer of TCR-transgenic CD8+ T cells specific for premelanosome protein (PMEL) (60), was later adapted to create a simpler vitiligo model by eliminating the B16 inoculation and using a host with epidermal pigmentation for the transfer (61). This evidence concerns the gene CD8A and melanoma.