CX3CR1 and Ascending tubular aorta aneurysm: As a result, RS504393 also efficiently suppressed Ly6Chi monocyte recruitment and subsequent CX3CR1+ macrophage accumulation in aneurysmal aortas (Figure 6E), thereby ameliorating the progression of aortic root and ascending aortic aneurysms in Fbn1C1041G/+ mice (Figure 6, F–H, and Supplemental Figure 15B).