In accordance, transthoracic echocardiography showed that DT-induced elimination of CX3CR1+ macrophages/monocytes greatly ameliorated both aortic root and ascending aortic aneurysm progression as well as related aortic wall pathologies in Cx3cr1-CreERT2iDTRF/+Fbn1C1041G/+ mice (Figure 2, D–F). The gene discussed is CX3CR1; the disease is Ascending tubular aorta aneurysm.