CSF1R and thoracic aortic aneurysm: Of note, a recent study clarified the pathogenic role of macrophages in a β-aminopropionitrile–induced (BAPN-induced) thoracic aortic aneurysm and dissection (TAAD) mouse model, as evidenced by the fact that suppression of macrophage accumulation in the aorta by using the CSF1R inhibitor Ki20227 decreased the incidence of TAAD and aortic rupture in mice (32).