BAP1 and uveal melanoma: To investigate how the deubiquitinase activity of BAP1 is involved in the transcriptional regulation in uveal melanoma cells, we reexpressed either WT or catalytically dead (C91S) BAP1 in the BAP1-null MP65 cell line (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI179703DS1).